Osmotic Fragility of Red Blood Cells, Secondary Hyperparathyroidism, and Uremia

III RESULTS OF TESTS FOR HAEMOLYSIS AND FOR OSMOTIC FRAGILITY OF RED BLOOD CELLS Osmotic Fragility

SYNOPSIS Nineteen patients with morphological abnormalities of the red blood cells are described, and these formed approximately 3 % of the total cases of cardiac valvular disease. In two patients the abnormal blood film developed after the insertion of an aortic and mitral valve prosthesis respectively, but in another two patients the abnormal blood film was corrected by aortic valve surgery. ...

hematological parameters and osmotic fragility of red blood cells in experimentally induced hyperthyroidism in rats

Osmotic fragility of normal and sickle haemoglobin containing red blood cells.

Abnormalities in osmotic fragility have been observed in hereditary spherocytosis, hereditary elliptocytosis, pyruvate kinase deficiency, thalassaemia and iron-deficient red cells (1). Harris et al have reported a decrease in osmotic fragility of the red cells of sickle cell anaemia patients from Africa (2). The Indian patients are genetically and clinically different from the African patients ...

Parathyroid hormone and anaemia--an erythrocyte osmotic fragility study in primary and secondary hyperparathyroidism.

Parathyroid hormone (PTH) has been shown in vitro to enhance erythrocyte osmotic fragility (EOF) and has been incriminated as a factor in the anaemia seen in patients with primary hyperparathyroidism and in patients with renal disease and secondary hyperparathyroidism. Enhanced EOF has also been shown in patients with chronic renal failure but did not correlate with PTH levels. We studied a gro...

Hyperglycemia can cause membrane lipid peroxidation and osmotic fragility in human red blood cells.

The present study has examined the effect of elevated glucose levels on membrane lipid peroxidation and osmotic fragility in human red blood cells (RBC). Defibrinated whole blood or RBC were incubated with varying concentrations of glucose at 37 degrees C for 24 h. RBC incubated with elevated levels of glucose showed a significantly increased membrane lipid peroxidation when compared with contr...